Now the Palacio de Congresos y Exposiciones, it was built at the beginning of the 16th century and was the only hospital in the city for two centuries.
The building is arranged around an arcaded cloister in the Mudejar style with semicircular arches. One of the most striking elements is the Gothic façade of the chapel of the old hospital, also the work of Hernán Ruiz I. Also worth a visit is the Sala Julio Romero de Torres, installed in what used to be the maternity wing of the hospital and which still conserves the original 16th century frescoes that reproduce passages from the life of San Sebastián.
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